I'm a little confused. Do you mean so many references/times bane has shown up in the comic... or the hamlet name reference & bane both being on the page... or...?
Oh sure. Just as there are some that aren't into drinking. I know Kevin (whom you saw serving at Basil Burger) is a character you've "met" who's into neither. Basil may not like bane either - I'd have to ask him. :) Other characters yet to come don't like it. And Talbot had barely if ever been able to get his paws on it prior to finding the town. But a good enough number do use bane to warrant the Bane of Your Existence shop in Bisclavret. Also, considering that the CoyWolves have their 'special' bane business, it is a large part of the comic.
there must be at least a few who don't like to smoke.